Ole Gunnar Solskjaer against Bayern Munich and Liverpool spring to mind, as does Michael Owen against Manchester City.
Harry Maguire has now added his name to that list after scoring in extra time to complete a stunning United fightback against Lyon.
United drew 2-2 with Lyon last week but appeared to be down and out against 10 men, trailing 4-2 on the night with just 10 minutes to play.
Bruno Fernandes and Kobbie Mainoo dragged United level, but there was more drama to come as Maguire headed home the winner to spark absolute bedlam inside Old Trafford
Andre Onana shares four-word message after Manchester United win
There have been some bonkers nights at Old Trafford over the years, but few will match the madness against Lyon.
United were up, down, out, back in and suddenly through to the semi-finals in a topsy-turvy night.
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